Direct involvement of hepcidin in iron metabolism creates a prerequisite for the treatment of anemia. The necessity oftreating anemia in patients with pneumonia under hospital conditions is a matter of discussion.
The curreni literature contains few data on the use of hepcidin as a diagnostic marker of anemia. During pneumonia resolution, hepsidin promotes recovery from anemia by activating iron absorption. Hypoxia and anemia activate erythtropoiesis, and the released erythropoietin inhibits hepsidin production. Hepsidin production increases during inflammation it suppresses erythtropoiesis and depletes the iron depot leading to so-called anemia of inflammation. Hepcidin, a mediator of inflammation and iron-regulatory hormone, plays an important role in the clinical course of community-acquired pneumonia. Severe anemia results in enhanced hypercapnia and slowed maturation of red blood cells in the bone marrow which facilitates the development of ischemic syndrome. Not infrequently, anemia is not diagnosed during the hospital stay und therefore remains uncorrected. Up to 30% of the patients present with anemia responsible for the unfavourable prognosis and elevated mortality. I advise you to follow up with your Doctor.Community-acquired pneumonia remains a most widespread acute infectious disease of socio-economic significance all over the world. The increase is usually temporary and resolve once the cause is treated. 26.1, P 0.02) with no difference in the use of autologous blood. The allogeneic transfusion rate was substantially reduced in hospitals randomized to the blood conservation algorithm compared with usual care (16.5 vs. The increase in the red blood cell count is not high enough to search for a cuase for primary erythrocytosis (RBCs or bone marrow causes), however, an apparent erythrocytosis( red cells are more concentrated), can be considered. Transfusion triggers were set at hemoglobin less than 7 g/dl or hemoglobin between 7 and 10 g/dl and symptoms. Patients with clinically significant cyclic neutropenia (ANC less than 200 cells/µl) (0.2 x 109/l) may have some symptoms with each cycle, but significant infections are infrequent. Other blood cells, such as platelets or red cells may also with a cyclical pattern.Ĭyclic neutropenia may be sporadically, or run in families. (at least 3 times per week over six weeks) to search for the disease.
Is a cycling of these counts normal? Are the RBC significantly elevated that I should be concerned about them? Could my blood levels be causing the fatigue?Ĭyclic neutropenia is considered if on serial differential blood counts a typical cyclical pattern of blood neutrophils count is seen. Then they return to a more normal level though my red cell counts are always right at the very top of normal and my neutrophil counts are at the very bottom of normal.
This has happened in the past where my RBC, Hemoglobin and Hematocrit were elevated and my neutrophils were low (as low as 1.2 at one point) but my RBC have never been this high. My doctor ran bloodwork and the following came back: I have been feeling EXHAUSTED lately and went to my doctor.